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Lesions and targeting of neuro-glio-epithelial unit during irritable bowel syndrome

Par : Lilli, Nicoletta Libéra

Document archivé le : 09/09/2016

The irritable bowel syndrome (IBS) is a multifactorial complex disorder characterized by chronic abdominal pain and altered bowel habits. Emerging evidences suggest that the increase of the para-cellular permeability may contribute to the pathophysiology of IBS. Consequently, therapeutic approaches to improving the homeostasis of the intestinal epithelial barrier (IEB) could be of great interest in the management of IBS. Among the responsible actors for IEB lesions there are the alterations of gut microbiota, which have been identified in IBS. The ability of bacterial strains/probiotics to repair the IEB could be of therapeutic value. Other factors involved in the alterations of the digestive functions in IBS include the enteric nervous system (ENS) in particular, enteric glial cells (EGC). However, the alterations of EGC in IBS remain to be determined. In this context, my thesis consisted firstly to identify the ability of a probiotic strain to protect the IEB from lesions induced by proteolytic mediators via 1) increase in the expression of tight junction proteins 2) modulation of cytokine production by IEC. On the other hand, my research showed phenotypic and functional alterations of EGC and identified histamine as a responsible actor of these altrations. 16NANT05-VS


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